Un mécanisme moléculaire intéressant pour lutter contre l'obésité

Body weight reflects the balance between energy intake and consumption. Biological systems have evolved in an environment with ample demand for physical activity and restricted food supply, presenting a selection bias for mechanisms that conserve energy (Celi, 2009). Although naturally protective, however, these energy-conserving systems under conditions of hyperalimentation and sedentary lifestyle promote obesity (Schwartz et al., 2003,Ogden et al., 2006). Hence, comprehension of energy-conserving mechanisms and interference with their efficiency could advance obesity treatment and prevention. The ATP-sensitive K+ (KATP) channel, due to a unique ability to integrate energy cues with membrane excitability-dependent processes, may represent such an energy-controlling mechanism (Miki and Seino, 2005,Ashcroft, 2005,Alekseev et al., 2005,Nichols, 2006). Widely expressed in excitable tissues, KATP channels are formed by tissue-specific multimerization of pore-forming Kir6.x with regulatory SURx subunits (Inagaki et al., 1995,Yamada et al., 1997,Babenko et al., 1998), yet their adenine nucleotide sensing function remains consistent throughout the body (Nichols et al., 1996,Aguilar-Bryan et al., 2001,Ashcroft, 2005,Zingman et al., 2003). Sarcolemmal KATP channels (Kir6.2/SUR2A) are increasingly recognized as safety valves

Voir : http://www.cell.com/cell-metabolism/fulltext/S1550-4131(09)00373-8

Copyright

Réagir

Vos réactions

Soyez le premier à réagir !

Les réactions aux articles sont réservées aux professionnels de santé inscrits
Elles ne seront publiées sur le site qu’après modération par la rédaction (avec un délai de quelques heures à 48 heures). Sauf exception, les réactions sont publiées avec la signature de leur auteur.

Réagir à cet article